The generation of high-order harmonics (HHG) is a strongly nonlinear process known for three decades. It forms the basis for attosecond pulse generation techniques and serves as the most practical solution for generating high-frequency coherent light (extending up to soft X-rays). HHG has undergone two fundamental advances in recent years: (1) the demonstration of the process’s capability to generate structured light, a field in which we were pioneers and extensively explored in research line #1; (2) the replacement of gaseous nonlinear material with nanostructured solid targets. This second aspect has led to the use of HHG not only as a new tool for generating structured light beams but also for exploring the quantum dynamics occurring in solids. The current research line corresponds to our work combining these two scenarios. At USAL, we have developed theoretical models that allowed us to describe HHG in two-dimensional materials, with special attention to graphene. Noteworthy is the work on describing the anisotropy in the nonlinear response of graphene [Optics Express, 27(5), 7776–7786 (2019), >50 citations].